The Holy Spirit miraculously sanctified that which was conceived and produced in the womb of the Virgin, so that original sin did not attach itself to that which was thus formed; for it did not become the Word, the Son of God, to assume a nature polluted with sin, for the following reasons: 1. That he might be a pure sacrifice; for it was necessary for him to make satisfaction for sin. 2. That he might also, by his purity, sanctify others. 3. That we might know that whatever the Son says is truth; for that which is born of flesh, which is sinful, and not sanctified, is flesh, falsehood and vanity. [1]
[1] Zacharias Ursinus, The Commentary of Dr. Zacharias Ursinus on the Heidelberg Catechism, Trans. Rev. G. W. Williard, A. M. Electronic version Ed. Eric D. Bristley, TH.M. (2004), 384.